In Vitro Permeability Study Preparations Gel Diclofenac Sodium and Diethyl amine Diclofenac
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چکیده
منابع مشابه
Tolerability of diclofenac sodium 1% gel with concomitant medications known to interact with diclofenac
BACKGROUND Topical diclofenac sodium 1% gel (DSG) has demonstrated efficacy and tolerability in patients with osteoarthritis (OA) of the knees or hands, including elderly patients and those with an increased risk of gastrointestinal, cardiovascular, and renal adverse events (AEs). Medications known to interact with diclofenac were disallowed in a clinical trial of DSG for knee OA; however, pati...
متن کاملSpectrophotometric Determination of Diclofenac in Pharmaceutical Preparations
Neste trabalho é proposto um método espectrofotométrico modificado para a determinação de diclofenaco em preparações farmacêuticas. Usa-se solução de cobre(II) como reagente, o que leva à formação de um complexo cobre(II)-diclofenaco de cor verde, com máximo de absorção em 680 nm. Foram estudadas as influências: do pH; da concentração de cobre(II); do uso de ácido acético na solução de cobre(II...
متن کاملIn vitro investigation of sodium diclofenac adsorption on sucralfate.
Adsorption of sodium diclofenac was investigated in the presence of sucralfate--a cytoprotective agent preventing gastropathy, adverse effect of diclofenac. Evaluation of adsorption was performed by means of a static method in vitro taking into account pH of the environment, temperature, concentration of the investigated agents and the form of sucralfate. Findings obtained prove that sodium dic...
متن کاملA comparison of gastrointestinal permeability induced by diclofenac-phospholipid complex with diclofenac acid and its sodium salt.
PURPOSE Gastrointestinal (GI) side effects of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac may be reduced if it is administered as a complex with phospholipid. The upper and lower GI permeability induced by a diclofenac-dipalmitoyl phosphatidyl choline (DPPC) complex were compared with those of diclofenac acid and its sodium salt in rats. METHODS Pharmacokinetic studies were car...
متن کاملA pharmacokinetic study of diclofenac sodium in rats.
The aim of the present study was to examine the pharmacokinetics of a single intravenous injection (i.v.) and oral administration (p.o.) of diclofenac sodium (DIC) in Sprague-Dawley (SD) rats. Twelve male SD rats were divided into 2 groups (n=6 per group); one group was injected intravenously with 2 mg/kg DIC, whereas the other group was lavaged with 2 mg/kg DIC. Blood samples were collected pr...
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ژورنال
عنوان ژورنال: Indonesian Journal of Pharmaceutical Science and Technology
سال: 2014
ISSN: 2356-1971,2406-856X
DOI: 10.15416/ijpst.v1i2.7514